Some antihypertensive drugs have smaller blood pressure effects (as monotherapy) in black patients, and many antihypertensive drugs have additional approved indications and effects (e.g., on angina, heart failure, or diabetic kidney disease). Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension (e.g., patients with diabetes or hyperlipidemia), and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal. The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke, but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly.Įlevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits.
For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program’s Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC). Many patients will require more than one drug to achieve blood pressure goals. There are no controlled trials in hypertensive patients demonstrating risk reduction with Diovan.Ĭontrol of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes, including the class to which valsartan principally belongs. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. The inactive ingredients of the tablets are colloidal silicon dioxide, crospovidone, hydroxypropyl methylcellulose, iron oxides (yellow, black and/or red), magnesium stearate, microcrystalline cellulose, polyethylene glycol 8000, and titanium dioxide.ĭiovan®(valsartan) is indicated for the treatment of hypertension, to lower blood pressure in adults and pediatric patients six years of age and older. It is soluble in ethanol and methanol and slightly soluble in water.ĭiovan is available as tablets for oral administration, containing 40 mg, 80 mg, 160 mg or 320 mg of valsartan. Valsartan is a white to practically white fine powder. Its empirical formula is C 24H 29N 5O 3, its molecular weight is 435.5, and its structural formula is:
Valsartan is chemically described as N-(1-oxopentyl)- N-4- yl]methyl]-L- valine. (see WARNINGS AND PRECAUTIONS)ĭiovan (valsartan) is a nonpeptide, orally active, and specific angiotensin II receptor blocker acting on the AT 1 receptor subtype. Drugs that act directly on the renin-angiotens in system can cause injury and death to the developing fetus.When pregnancy is detected, discontinue Diovan as soon as possible.You may report side effects to FDA at 1-80. For more information, ask your doctor or pharmacist.Ĭall your doctor for medical advice about side effects. These are not all the possible side effects of Diovan. Tell the doctor if you have any side effect that bothers you or that does not go away. The most common side effects of Diovan include: Get medical help right away, if you have any of the symptoms listed above. What are the possible side effects of Diovan?ĭiovan may cause serious side effects including: It is not known if Diovan is safe and effective in children younger than 6 years of age.
Diovan may be used alone or with other medications.ĭiovan belongs to a class of drugs called ARBs. Find Lowest Prices on What is Diovan and how is it used?ĭiovan is a prescription medicine used to treat the symptoms of high blood pressure ( hypertension), heart failure, and to prevent death after a heart attack.
0 kommentar(er)
